During neuronal synaptic transmission, the exocytotic release of neurotransmitters from synaptic vesicles in the presynaptic neuron evokes a change in conductance for one or more types of ligand-gated ion channels in the postsynaptic neuron.The standard method of investigation uses electrophysiological recordings of the postsynaptic response.Howeve
Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt
Abstract Background Many cancers arise from mutations in cells within epithelial tissues.Mutations manifesting at the subcellular level influence the structure COFFEE LIONS MANE and function of the tissue resulting in cancer.Previous work has proposed how cell level properties can lead to mutant cell invasion, but has not incorporated detailed subc
Modulating temporal dynamics of performance across retinotopic locations enhances the generalization of perceptual learning
Summary: Human visual perception can be improved through perceptual learning.However, such learning is often specific to stimulus and learning conditions.Here, we explored how temporal dynamics of performance across conditions impact learning generalization.Participants performed a visual task, with the target at retinotopic location A.Then, the ta
The imperative of evidence-based health workforce planning and implementation: lessons from nurses and midwives unemployment crisis in Ghana
Abstract Following periods of health workforce crisis characterised by a severe shortage of nurses, midwives and doctors due to low production rates and excessive out-migration, the Government of Ghana through the Ministry of Health (MOH) responded by expanding training and allowing private sector involvement in the training of health workers espec
Typical performance behavior of a Diesel cycle agricultural tractor engine with electronic injection management and turbocharger
ABSTRACT: Over the past few years, changes have been observed in the behavior of typical performance TOSLINK Optical curves, after higher technology has been incorporated into the agricultural tractor engines, either to satisfy the ceiling of the new pollutant gas emission limits or to achieve better efficiency.The aim of this study was to assess t